Creating mouse models to study genetic disorders like Down syndrome
REPOSITORY OF MOUSE MODELS FOR CYTOGENETIC RESEARCH
['FUNDING_OTHER'] · JACKSON LABORATORY · NIH-11194923
This study is creating special mice that have traits similar to those seen in people with Down syndrome, so researchers can learn more about the condition and find ways to help families affected by it.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JACKSON LABORATORY (nih funded) |
| Locations | 1 site (BAR HARBOR, UNITED STATES) |
| Trial ID | NIH-11194923 on ClinicalTrials.gov |
What this research studies
This research focuses on developing and distributing mouse models that mimic human genetic disorders, particularly Down syndrome, which is caused by an extra copy of chromosome 21. By studying these models, researchers aim to better understand the biological mechanisms behind intellectual disabilities and related conditions. The project involves generating genetically modified mice and analyzing their behavior and physiology to draw parallels with human conditions. Patients and families affected by Down syndrome may benefit from insights gained through this research.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with Down syndrome or related intellectual disabilities.
Not a fit: Patients with non-genetic intellectual disabilities or those without a diagnosis related to chromosome abnormalities may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for genetic disorders like Down syndrome.
How similar studies have performed: Previous research using mouse models for genetic disorders has shown promising results, indicating that this approach is both established and valuable.
Where this research is happening
BAR HARBOR, UNITED STATES
- JACKSON LABORATORY — BAR HARBOR, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LUTZ, CATHLEEN — JACKSON LABORATORY
- Study coordinator: LUTZ, CATHLEEN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease