Creating mouse models to study DNA methylation effects
Official title: Developing mouse models for functional studies of locus-specific DNA methylation
Funded at Baylor College of Medicine · NIH-11115427 · Data updated 2026-11-12
This study is all about creating special mouse models to help scientists understand how changes in DNA can affect health and diseases, which could eventually lead to better treatments for patients dealing with these conditions.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | April 1, 2025 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $143,800 |
| NIH project number | 1R21OD038402-01 |
| Project ID | NIH-11115427 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research include individuals with conditions influenced by epigenetic factors, such as certain cancers or genetic disorders.
✕Less likely to help
Patients with conditions unrelated to DNA methylation or those not affected by epigenetic changes may not benefit from this research.
What this research studies
This research focuses on developing mouse models that allow scientists to manipulate DNA methylation, a crucial process that influences gene expression and is linked to various diseases. By using advanced techniques like CRISPR/Cas9, the researchers aim to create tools that enable precise editing of DNA methylation in living organisms. This approach will help uncover the roles of DNA methylation in health and disease, providing insights that could lead to new therapeutic strategies. Patients may benefit from the findings as they could lead to better understanding and treatment of conditions influenced by epigenetic changes.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding and treating diseases related to DNA methylation.
How similar studies have gone: Other research has shown promise in using similar genetic manipulation techniques to study epigenetic factors, indicating a potential for success in this area.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Shen, Lanlan — Baylor College of Medicine
- Study coordinator: Shen, Lanlan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.