Creating mouse models to study arsenic toxicity in humans
Humanized mouse models for arsenic toxicology
This study is creating special mouse models to help us understand how arsenic, a harmful substance found in some drinking water and food, affects our health, especially in relation to diseases like cancer and diabetes, so we can learn more about how our bodies deal with it and why some people are more affected than others.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-10871869 on NIH RePORTER |
What this research studies
This research focuses on developing advanced mouse models that mimic human metabolism of inorganic arsenic, a harmful contaminant found in drinking water and food. By understanding how arsenic affects human health, particularly in relation to diseases like cancer and diabetes, the researchers aim to create models that can accurately replicate the adverse effects seen in humans. The study will explore the mechanisms of arsenic detoxification and the genetic factors that influence individual responses to arsenic exposure. This approach will allow for more relevant testing of arsenic's health impacts at levels that people typically encounter in their environment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals exposed to inorganic arsenic through drinking water or food sources.
Not a fit: Patients who have not been exposed to inorganic arsenic or those with unrelated health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention of arsenic-related health issues in humans.
How similar studies have performed: Previous research has shown success in using animal models to study toxic substances, but this approach to humanizing mouse models for arsenic is relatively novel.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Styblo, Miroslav — Univ of North Carolina Chapel Hill
- Study coordinator: Styblo, Miroslav
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.