Creating mouse models to study Alzheimer's disease-related dementia genetics
Full human gene-replacement mouse models of ADRDs
['FUNDING_OTHER'] · UNIVERSITY OF MINNESOTA · NIH-10464809
This study is creating special mice that have human genes linked to Alzheimer's disease to help scientists learn more about how these genes cause problems in the brain and to find new ways to treat the disease.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MINNESOTA (nih funded) |
| Locations | 1 site (MINNEAPOLIS, UNITED STATES) |
| Trial ID | NIH-10464809 on ClinicalTrials.gov |
What this research studies
This research focuses on developing mouse models that closely mimic the genetic aspects of Alzheimer's disease-related dementias (ADRDs). By using advanced Gene Replacement technology, researchers will replace mouse genes with their human counterparts to better understand the molecular dysfunctions caused by specific genetic mutations associated with ADRDs. These models will help identify early-stage indicators of the disease and test potential therapeutic interventions aimed at correcting these genetic issues.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a family history of Alzheimer's disease or related dementias, particularly those with known genetic mutations.
Not a fit: Patients without a genetic predisposition to Alzheimer's disease-related dementias may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for Alzheimer's disease-related dementias, improving patient outcomes.
How similar studies have performed: Other research has shown success in using genetic mouse models to study neurodegenerative diseases, indicating a promising approach for this project.
Where this research is happening
MINNEAPOLIS, UNITED STATES
- UNIVERSITY OF MINNESOTA — MINNEAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KOOB, MICHAEL D — UNIVERSITY OF MINNESOTA
- Study coordinator: KOOB, MICHAEL D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.