Creating models to understand how certain proteins bind manganese and iron for potential medical uses
Official title: Biomimetic models of manganese- and iron-histidine coordination sites in metalloproteins for chelation, antibiotic activity, and oxidative reactivity
Funded at Mississippi State University · NIH-10797888 · Data updated 2026-11-12
This study is looking at how certain proteins in your immune system grab onto metals like manganese and iron, and it's for anyone interested in new ways to improve treatments for conditions caused by metal imbalances and to make antibiotics work better.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mississippi State University NIH-funded |
| Lab location | 1 site (Mississippi State, United States) |
| Project start | August 1, 2021 |
| Project end | July 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $18,728 |
| NIH project number | 3R15GM143702-01S1 |
| Project ID | NIH-10797888 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would include individuals with conditions related to manganese or iron metabolism, as well as those who may benefit from improved antibiotic treatments.
✕Less likely to help
Patients with conditions unrelated to metal binding or those who do not require antibiotic treatments may not benefit from this research.
What this research studies
This research focuses on understanding how specific proteins in the immune system, like calprotectin, bind manganese and iron. By developing models that mimic these proteins, the researchers aim to create new chelating agents that can selectively bind these metals. The approach involves synthesizing novel ligands and using various scientific techniques to study their properties and effectiveness. This could lead to advancements in treatments for conditions related to metal imbalances and improve antibiotic efficacy.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for conditions caused by metal imbalances and enhance the effectiveness of antibiotics.
How similar studies have gone: While the specific approach of using bioinspired models for manganese and iron binding is relatively novel, similar research in metal chelation has shown promising results in other contexts.
Where this research is happening
-
Mississippi State University
Mississippi State, United States Active
Researchers
- Principal investigator: Creutz, Sidney E — Mississippi State University
- Study coordinator: Creutz, Sidney E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.