Creating models to understand brain damage and dementia after injuries
Developing Gyrencephalic Models of TBI-Induced ADRD Neuropathology
['FUNDING_OTHER'] · UNIVERSITY OF PENNSYLVANIA · NIH-10933868
This study is looking at how long-term effects of traumatic brain injuries might be connected to Alzheimer's and other types of dementia, and it's designed to help people understand how these injuries can lead to memory problems in the future, which could lead to better treatments and prevention strategies.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10933868 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the long-term effects of traumatic brain injury (TBI) and its link to Alzheimer's disease and related dementias. By developing new models that mimic the complex brain changes following TBI, the researchers aim to explore the underlying mechanisms of neurodegeneration. The study will utilize various injury scenarios to replicate real-world conditions, allowing for a better understanding of how these injuries can lead to dementia. Patients may benefit from insights gained through this research, which could inform future treatments and preventive strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have experienced traumatic brain injuries, particularly those with a history of contact sports participation.
Not a fit: Patients who have not experienced any form of traumatic brain injury or those with other unrelated forms of dementia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients suffering from dementia related to traumatic brain injuries.
How similar studies have performed: Previous research has shown promise in understanding the relationship between TBI and neurodegeneration, but this approach to developing gyrencephalic models is relatively novel.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JOHNSON, VICTORIA ELEANOR — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: JOHNSON, VICTORIA ELEANOR
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired brain injury, Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease, Alzheimer's disease and related dementia