Creating models to understand brain damage and dementia after injuries
Official title: Developing Gyrencephalic Models of TBI-Induced ADRD Neuropathology
Funded at University of Pennsylvania · NIH-10933868 · Data updated 2026-11-12
This study is looking at how long-term effects of traumatic brain injuries might be connected to Alzheimer's and other types of dementia, and it's designed to help people understand how these injuries can lead to memory problems in the future, which could lead to better treatments and prevention strategies.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | August 15, 2024 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $3,102,638 |
| NIH project number | 1RF1NS138030-01 |
| Project ID | NIH-10933868 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who have experienced traumatic brain injuries, particularly those with a history of contact sports participation.
✕Less likely to help
Patients who have not experienced any form of traumatic brain injury or those with other unrelated forms of dementia may not benefit from this research.
What this research studies
This research focuses on understanding the long-term effects of traumatic brain injury (TBI) and its link to Alzheimer's disease and related dementias. By developing new models that mimic the complex brain changes following TBI, the researchers aim to explore the underlying mechanisms of neurodegeneration. The study will utilize various injury scenarios to replicate real-world conditions, allowing for a better understanding of how these injuries can lead to dementia. Patients may benefit from insights gained through this research, which could inform future treatments and preventive strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients suffering from dementia related to traumatic brain injuries.
How similar studies have gone: Previous research has shown promise in understanding the relationship between TBI and neurodegeneration, but this approach to developing gyrencephalic models is relatively novel.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Johnson, Victoria Eleanor — University of Pennsylvania
- Study coordinator: Johnson, Victoria Eleanor
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.