Creating models to support embryo development outside the body
Placental models to support embryogenesis in vitro
This study is exploring how embryos attach and grow in the uterus, which is a key step where many pregnancies can struggle, and it's designed to help people facing fertility challenges by creating lab models that mimic the natural environment of the uterus.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | California Institute of Technology NIH-funded |
| Lab location | 1 site (Pasadena, United States) |
| Project ID | NIH-10881737 on NIH RePORTER |
What this research studies
This research investigates the critical stage of embryo implantation, which is often where pregnancies fail. By developing synthetic models that mimic the natural environment of the uterus, the research aims to understand the mechanisms that allow embryos to implant and grow. The approach includes engineering synthetic blastocysts and creating supportive environments that can sustain embryo development in vitro. This could provide insights into fertility issues and improve assisted reproductive technologies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing infertility or those interested in assisted reproductive technologies.
Not a fit: Patients who are not seeking fertility treatments or have no interest in assisted reproduction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved outcomes for patients undergoing fertility treatments and enhance our understanding of early human development.
How similar studies have performed: Other research has shown promise in using synthetic models to study embryo development, indicating that this approach could yield valuable insights.
Where this research is happening
Pasadena, United States
- California Institute of Technology — Pasadena, United States (Active)
Researchers
- Principal investigator: Zernicka-Goetz, Magdalena — California Institute of Technology
- Study coordinator: Zernicka-Goetz, Magdalena
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.