Creating models to study rare neuroendocrine tumors for better treatment options
Addressing biological and therapeutic gaps in rare neuroendocrine cancer with a novel organoid-based model
This study is creating tiny models of rare tumors called pheochromocytomas and paragangliomas to help us understand how they work and find new treatments, which could lead to better care for patients dealing with these challenging cancers.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-10894934 on NIH RePORTER |
What this research studies
This research focuses on developing organoid models of pheochromocytomas and paragangliomas, which are rare tumors that secrete catecholamines and can originate from adrenal glands or other areas. By creating these models, the research aims to better understand the biological mechanisms behind these tumors and identify potential therapeutic targets. The approach involves generating organoids that mimic the characteristics of the actual tumors, allowing for drug screening and investigation of tumor behavior. This could lead to improved clinical outcomes for patients with these aggressive and often late-diagnosed cancers.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with pheochromocytomas or paragangliomas, particularly those with aggressive or recurrent forms of these tumors.
Not a fit: Patients with common types of cancer or those without a diagnosis of pheochromocytomas or paragangliomas may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments and better prediction of clinical outcomes for patients with rare neuroendocrine tumors.
How similar studies have performed: Other research has shown promise in using organoid models for studying rare cancers, indicating that this approach could be effective.
Where this research is happening
San Antonio, United States
- University of Texas Hlth Science Center — San Antonio, United States (Active)
Researchers
- Principal investigator: Dahia, Patricia Leal — University of Texas Hlth Science Center
- Study coordinator: Dahia, Patricia Leal
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.