Creating models to study how diseases affect men and women differently
Bioengineering Microphysiological Models of Sex-Specific Pathophysiology
['FUNDING_OTHER'] · TULANE UNIVERSITY OF LOUISIANA · NIH-11062345
This study is looking at how male and female cells respond differently to hormones and diseases, which could help create better and more personalized treatments for conditions like diabetic retinopathy.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TULANE UNIVERSITY OF LOUISIANA (nih funded) |
| Locations | 1 site (NEW ORLEANS, UNITED STATES) |
| Trial ID | NIH-11062345 on ClinicalTrials.gov |
What this research studies
This research aims to develop advanced microphysiological systems that mimic human diseases while considering sex differences. By using both 2D and 3D cell culture techniques, the project will investigate how hormones like estrogen and androgen influence cellular behavior in male and female cells. The goal is to enhance the accuracy of drug testing and therapeutic approaches by understanding how sex-specific factors affect disease mechanisms. This could lead to more personalized and effective treatments for conditions like diabetic retinopathy.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions influenced by hormonal differences, such as diabetic retinopathy.
Not a fit: Patients with conditions unrelated to hormonal influences or those not affected by sex-specific pathophysiology may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and tailored treatments for diseases that affect men and women differently.
How similar studies have performed: While the approach of using sex-specific models is gaining attention, this particular methodology of systematically comparing sex-matched and cross-sex hormone stimulation in cultured human cells is relatively novel.
Where this research is happening
NEW ORLEANS, UNITED STATES
- TULANE UNIVERSITY OF LOUISIANA — NEW ORLEANS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MONDRINOS, MARK — TULANE UNIVERSITY OF LOUISIANA
- Study coordinator: MONDRINOS, MARK
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.