Creating models to improve treatments for chronic myelomonocytic leukemia
Developing and credentialing patient-derived xenograft models to advance therapeutic approaches for chronic myelomonocytic leukemia
This study is looking at chronic myelomonocytic leukemia (CMML) to find new treatments by using special models that mimic the disease, and it also explores how a certain type of immune cell might affect how the disease behaves and responds to therapy.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | H. Lee Moffitt Cancer Ctr & Res Inst NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-10798431 on NIH RePORTER |
What this research studies
This research focuses on chronic myelomonocytic leukemia (CMML), a serious type of leukemia. The team has developed patient-derived xenograft (PDX) models that accurately reflect the disease's characteristics, allowing for better understanding and treatment options. By studying these models, researchers aim to identify new therapies that target specific genetic features and signaling pathways in CMML. The project also explores the interaction between CMML and a unique mast cell clone found in some patients, which may influence disease progression and treatment response.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with chronic myelomonocytic leukemia, particularly those with specific genetic mutations or a concomitant mast cell clone.
Not a fit: Patients with other types of leukemia or those without chronic myelomonocytic leukemia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatment options for patients with chronic myelomonocytic leukemia.
How similar studies have performed: Previous research has shown promise in using patient-derived xenograft models for studying various cancers, indicating that this approach could be effective for CMML as well.
Where this research is happening
Tampa, United States
- H. Lee Moffitt Cancer Ctr & Res Inst — Tampa, United States (Active)
Researchers
- Principal investigator: Padron, Eric — H. Lee Moffitt Cancer Ctr & Res Inst
- Study coordinator: Padron, Eric
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.