Creating models of protein structures using advanced imaging techniques
Building protein structure models for intermediate resolution cryo-electron microscopy maps
['FUNDING_R01'] · PURDUE UNIVERSITY · NIH-10670831
This study is all about finding better ways to see and understand the shapes of proteins in 3D, which can help scientists learn more about how these proteins work and how they relate to diseases.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | PURDUE UNIVERSITY (nih funded) |
| Locations | 1 site (WEST LAFAYETTE, UNITED STATES) |
| Trial ID | NIH-10670831 on ClinicalTrials.gov |
What this research studies
This research focuses on improving the way scientists can visualize and understand the 3D structures of proteins using a technique called cryo-electron microscopy (cryo-EM). By developing new computational methods, the project aims to accurately model the structures of large biological macromolecules from cryo-EM maps, which are images produced by this advanced imaging technique. This could help in interpreting complex biological processes and diseases at a molecular level, ultimately enhancing our understanding of how proteins function in the body.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research include individuals with conditions related to protein misfolding or dysfunction, such as certain genetic disorders or neurodegenerative diseases.
Not a fit: Patients with conditions unrelated to protein structure or function may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to better insights into protein structures, which may improve the development of targeted therapies for various diseases.
How similar studies have performed: Other research in the field of cryo-electron microscopy has shown promising results in understanding protein structures, indicating that this approach has potential for success.
Where this research is happening
WEST LAFAYETTE, UNITED STATES
- PURDUE UNIVERSITY — WEST LAFAYETTE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KIHARA, DAISUKE — PURDUE UNIVERSITY
- Study coordinator: KIHARA, DAISUKE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.