Creating models of pre-cancerous colon cells
Human Pre-Cancer Models
This study is creating tiny models of colon tissue to learn more about how immune cells interact with early signs of colon cancer, helping researchers find better treatments for patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-10926869 on NIH RePORTER |
What this research studies
This research focuses on developing and characterizing pre-cancerous organoids from colon tissue, which are miniature, simplified versions of the colon that can be used for experimentation. The project involves isolating specific immune cells, such as neutrophils and cytotoxic T cells, from patients to study their interactions with these organoids. By building a repository of these models, the research aims to enhance understanding of colorectal cancer and support future studies that could lead to new treatments. Patients' genetic information will also be collected to better understand individual responses to cancer development.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of colorectal issues or those at high risk for developing colorectal cancer.
Not a fit: Patients with no history of colorectal issues or those who are not at risk for colorectal cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for early detection and treatment of colorectal cancer.
How similar studies have performed: Previous research has shown success in using organoid models to study cancer, indicating that this approach has potential for meaningful advancements.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Singh, Bhuminder — Vanderbilt University Medical Center
- Study coordinator: Singh, Bhuminder
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.