Creating models of pediatric brain tumors using patient-derived tissues
Matching panels of in vivo and in vitro model system of pediatric brain tumors
This study is working on creating better models of pediatric brain tumors using samples from patients to help understand how these tumors grow and interact, which could lead to improved treatments for kids with brain cancer.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lurie Children's Hospital of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-10798251 on NIH RePORTER |
What this research studies
This research focuses on developing accurate models of pediatric brain tumors by utilizing patient-derived orthotopic xenograft (PDOX) models and autopsied normal brain tissues. The team aims to create matching tumor organoids that replicate the biology of original patient tumors, which is crucial for understanding tumor interactions and improving treatment strategies. By overcoming the challenges of obtaining normal brain tissues, the researchers will use cryopreserved cells from autopsies to generate viable brain cell models. This innovative approach could lead to better insights into brain tumor biology and potential therapies for affected children.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with brain tumors, particularly those who may have undergone autopsy.
Not a fit: Patients with brain tumors who are not eligible for autopsy or those with other unrelated conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and outcomes for children with brain tumors.
How similar studies have performed: Other research has shown promise in using patient-derived models for studying tumors, indicating that this approach could be effective.
Where this research is happening
Chicago, United States
- Lurie Children's Hospital of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Li, Xiaonan — Lurie Children's Hospital of Chicago
- Study coordinator: Li, Xiaonan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.