Creating models of acute myeloid leukemia to understand racial differences in treatment outcomes
Developing Acute Myeloid Leukemia Models with Diverse Ancestral Origins
['FUNDING_R21'] · WAKE FOREST UNIVERSITY HEALTH SCIENCES · NIH-11057667
This study is looking at how acute myeloid leukemia (AML) affects people from different backgrounds, especially focusing on why some groups, like non-Hispanic black patients, may have worse outcomes, with the goal of finding better and more personalized treatments for everyone with AML.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | WAKE FOREST UNIVERSITY HEALTH SCIENCES (nih funded) |
| Locations | 1 site (WINSTON-SALEM, UNITED STATES) |
| Trial ID | NIH-11057667 on ClinicalTrials.gov |
What this research studies
This research focuses on acute myeloid leukemia (AML), a serious cancer affecting the bone marrow, particularly examining how it impacts patients of different ancestral backgrounds. The study aims to develop preclinical models that reflect the genetic diversity of patients, especially non-Hispanic black individuals, who often face worse outcomes compared to their non-Hispanic white counterparts. By utilizing advanced techniques to create these models, the researchers will investigate how these differences affect treatment responses and the underlying biological mechanisms. This could lead to more effective and personalized treatment strategies for AML patients based on their ancestral origins.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults diagnosed with acute myeloid leukemia, especially those who identify as non-Hispanic black.
Not a fit: Patients with acute myeloid leukemia who do not fall into the specified racial categories or who are not adults may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and outcomes for patients with acute myeloid leukemia, particularly those from diverse racial backgrounds.
How similar studies have performed: Previous research has shown that understanding genetic and ancestral differences can lead to significant advancements in treatment efficacy, suggesting that this approach has the potential for success.
Where this research is happening
WINSTON-SALEM, UNITED STATES
- WAKE FOREST UNIVERSITY HEALTH SCIENCES — WINSTON-SALEM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PARDEE, TIMOTHY SEBASTIAN — WAKE FOREST UNIVERSITY HEALTH SCIENCES
- Study coordinator: PARDEE, TIMOTHY SEBASTIAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.