Creating materials to help regenerate dental pulp tissue
Engineering Immunomodulatory Scaffolds for Dental Pulp Regeneration
This study is exploring new materials that can help your body heal damaged tooth tissue by encouraging your immune system to support regeneration instead of causing inflammation, which could lead to better treatments for teeth that have lost their vitality.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project ID | NIH-10767284 on NIH RePORTER |
What this research studies
This research focuses on developing innovative biomaterials that can modulate the immune response to promote the regeneration of dental pulp tissue. The approach involves engineering scaffolds that can influence immune cell behavior, particularly macrophages, to shift from a pro-inflammatory state to a pro-regenerative state. By understanding how these immune responses interact with the biomaterials, the research aims to create effective solutions for treating necrotic teeth and enhancing tissue healing. Patients may benefit from improved dental treatments that restore tooth vitality and function.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with necrotic teeth or those requiring dental pulp regeneration.
Not a fit: Patients with healthy teeth or those not requiring dental interventions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to advanced treatments for dental pulp regeneration, improving outcomes for patients with damaged or infected teeth.
How similar studies have performed: Other research has shown promising results in using biomaterials to modulate immune responses for tissue regeneration, indicating potential success for this approach.
Where this research is happening
Portland, United States
- Oregon Health & Science University — Portland, United States (Active)
Researchers
- Principal investigator: Miranda Franca, Cristiane — Oregon Health & Science University
- Study coordinator: Miranda Franca, Cristiane
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.