Creating long-lasting medications for HIV treatment

Prodrug Formulations Create Sustained-Release Antiretrovirals

NIH-funded research University of Nebraska Medical Center · NIH-11085799

This study is working on a new HIV medication that you could take just twice a year instead of every day, making it easier for you to stick to your treatment and stay healthy.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of Nebraska Medical Center NIH-funded
Lab location1 site (Omaha, United States)
Project IDNIH-11085799 on NIH RePORTER

What this research studies

This research focuses on developing new formulations of antiretroviral medications that can be administered less frequently, potentially every six months. By creating long-acting therapies, the goal is to improve patient adherence to treatment regimens and enhance overall health outcomes for individuals living with HIV. The research involves formulating a new drug, XVIR-110, which has already shown promise in safety studies and is moving towards clinical trials. Patients may benefit from a more convenient treatment schedule that reduces the need for frequent healthcare visits.

Who could benefit from this research

Good fit: Ideal candidates for this research are individuals living with HIV who are seeking more manageable treatment options.

Not a fit: Patients who are not living with HIV or those who prefer traditional daily medication regimens may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could provide patients with a more convenient and effective treatment option for managing HIV.

How similar studies have performed: Previous research has shown success with long-acting antiretroviral therapies, indicating a promising direction for this novel approach.

Where this research is happening

Omaha, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Acquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome Virus
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.