Creating kidney organoids to help with kidney transplants
Application of Progenitor Niche Signals to Ex Vivo Nephrogenesis
This study is working on creating tiny, lab-grown kidneys from special stem cells to help solve the shortage of kidney transplants, making it easier for patients to get the organ replacements they need.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rogosin Institute NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10877192 on NIH RePORTER |
What this research studies
This research focuses on developing kidney organoids from human induced pluripotent stem cells (iPSCs) to address the shortage of kidney transplants. The team aims to overcome challenges related to the integration of these organoids with the host's vascular and urinary systems. By identifying key obstacles such as tissue organization and tubular fusion, they plan to create better protocols and tools for successful kidney replacement therapy. Patients may benefit from advancements in organ transplant options through this innovative approach.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from chronic kidney failure or those on the waiting list for a kidney transplant.
Not a fit: Patients with acute kidney injury or those whose kidney function can be restored through other means may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly increase the availability of functional kidney tissue for transplantation.
How similar studies have performed: While the approach of using iPSC-derived organoids is promising, it is still largely experimental and has not yet been widely tested in clinical settings.
Where this research is happening
New York, United States
- Rogosin Institute — New York, United States (Active)
Researchers
- Principal investigator: Oxburgh, Leif — Rogosin Institute
- Study coordinator: Oxburgh, Leif
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.