Creating human skin models from stem cells
Generation of human skin organoids from pluripotency (Admin Supplement)
This study is all about creating tiny models of human skin to help find better treatments for skin issues like burns and wounds, and it’s for anyone interested in improving how we heal and understand skin sensitivity.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10861600 on NIH RePORTER |
What this research studies
This research focuses on developing human skin organoids using pluripotent stem cells, which can potentially lead to better treatments for skin-related conditions such as burns and wounds. The project aims to understand the necessary signals that guide the formation of skin cells and their appendages, like hair follicles and sweat glands. By modeling these processes in the lab, researchers hope to create more effective skin therapies. The study also explores pain pathways in skin organoids, which could enhance our understanding of skin sensitivity and healing.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who have skin injuries or conditions requiring innovative treatment approaches.
Not a fit: Patients with non-skin-related conditions or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to advanced therapies for skin injuries and conditions, improving healing and patient outcomes.
How similar studies have performed: Other research has shown promise in using stem cells to create skin models, indicating that this approach has potential for success.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Koehler, Karl Russell — Boston Children's Hospital
- Study coordinator: Koehler, Karl Russell
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.