Creating human skin models from stem cells
Generation of human skin organoids from pluripotency
['FUNDING_R01'] · BOSTON CHILDREN'S HOSPITAL · NIH-10689091
This study is working on a new way to grow tiny pieces of human skin from special stem cells, which could help create better treatments for burn injuries and other skin problems by providing a reliable source of skin for healing.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BOSTON CHILDREN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10689091 on ClinicalTrials.gov |
What this research studies
This research focuses on developing a method to create human skin organoids using pluripotent stem cells. By understanding the key signals needed to differentiate these stem cells into various skin cell types, the researchers aim to build complex skin structures that include essential components like hair follicles and sweat glands. This innovative approach could lead to improved treatments for burn injuries and other skin-related conditions by providing a reliable source of skin for therapy. The project utilizes a multi-stage 3D culture system to replicate the natural development of skin.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from severe burn injuries or skin conditions that require skin grafting or replacement.
Not a fit: Patients with non-skin-related conditions or those who do not require skin grafting may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide advanced therapies for patients with burn injuries and skin disorders by offering engineered skin that closely resembles natural human skin.
How similar studies have performed: Other research has shown promise in creating skin organoids from stem cells, indicating that this approach has potential for success.
Where this research is happening
BOSTON, UNITED STATES
- BOSTON CHILDREN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KOEHLER, KARL RUSSELL — BOSTON CHILDREN'S HOSPITAL
- Study coordinator: KOEHLER, KARL RUSSELL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Burn injury, Cancers