Creating human brain organoids to study neurodevelopmental disorders
Construction of the integrated human cortical organoids to investigate neurodevelopmental disorders
This study is exploring how certain genetic changes linked to conditions like schizophrenia and autism affect brain development by using tiny brain models made from human cells, helping us learn more about these disorders in a friendly and safe way.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10683134 on NIH RePORTER |
What this research studies
This research focuses on understanding the underlying mechanisms of neurodevelopmental disorders such as schizophrenia and autism spectrum disorders by using human brain organoids. These organoids are developed from human pluripotent stem cells, which can transform into various brain cell types, allowing researchers to mimic the developing human brain. By investigating specific genetic mutations associated with these disorders, the research aims to uncover how these mutations affect brain development and function. This innovative approach provides a unique opportunity to study human brain development in a controlled environment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with schizophrenia or autism spectrum disorders, particularly those with identified genetic mutations.
Not a fit: Patients without neurodevelopmental disorders or those whose conditions are not linked to genetic mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potential new treatments for neurodevelopmental disorders.
How similar studies have performed: Other research has shown promise in using human brain organoids to study various neurological conditions, indicating that this approach has potential for success.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Park, in-Hyun — Yale University
- Study coordinator: Park, in-Hyun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.