Creating genetically modified mouse and cell models to study cancer
Core 1: Mouse and Cell Modeling
This study is looking at how certain genes related to breast cancer work by creating special cell lines and mouse models, which could help us understand how our bodies repair DNA and lead to better treatments for cancer.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project ID | NIH-11080269 on NIH RePORTER |
What this research studies
This research focuses on developing genetically engineered cell lines and mouse models to better understand complex biological processes related to cancer. Using advanced CRISPR/Cas9 gene editing techniques, the team will modify human cell lines to investigate the BRCA gene network, which is crucial in breast cancer and other cancers. The project aims to create new research materials and repurpose existing mouse models to generate primary cell lines that can help elucidate how proteins involved in DNA repair function. By studying these models, researchers hope to gain insights into protein interactions and the efficiency of DNA damage repair, which could lead to improved cancer therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic predispositions to breast cancer, particularly those with mutations in the BRCA1 or BRCA2 genes.
Not a fit: Patients without genetic mutations related to breast cancer or those with other unrelated cancers may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for breast cancer and other related conditions by enhancing our understanding of DNA repair mechanisms.
How similar studies have performed: Previous research using similar gene editing techniques has shown promise in understanding cancer biology and developing targeted therapies.
Where this research is happening
Newark, UNITED STATES
- Rutgers Biomedical and Health Sciences — Newark, United States (Active)
Researchers
- Principal investigator: Xia, Bing — Rutgers Biomedical and Health Sciences
- Study coordinator: Xia, Bing
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.