Creating genetically modified marmosets to study sporadic Alzheimer's Disease
Genetic models of sporadic Alzheimers Disease in the marmoset
This study is creating special marmoset models to help us learn more about sporadic Alzheimer's Disease, so we can better understand how genes and the environment work together in this condition and find new ways to treat it.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Salk Institute for Biological Studies NIH-funded |
| Lab location | 1 site (La Jolla, UNITED STATES) |
| Project ID | NIH-10875596 on NIH RePORTER |
What this research studies
This research focuses on developing and validating genetically modified marmoset models to better understand sporadic Alzheimer's Disease (AD). By using marmosets, which share similarities with human brain structures and behaviors, researchers aim to investigate the complex interactions of genetic and environmental factors that contribute to AD. The study will utilize advanced gene editing techniques to create models that can mimic the disease more accurately than existing models, such as mice. This approach is expected to provide insights into the molecular and cellular mechanisms of AD and help identify potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research are individuals at risk for sporadic Alzheimer's Disease, particularly those with genetic predispositions such as the APOE ε4 allele.
Not a fit: Patients with familial forms of Alzheimer's Disease or those who do not carry genetic risk factors for sporadic Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for sporadic Alzheimer's Disease.
How similar studies have performed: Previous research using animal models has shown promise, but this approach with marmosets is relatively novel and aims to fill gaps left by existing models.
Where this research is happening
La Jolla, UNITED STATES
- Salk Institute for Biological Studies — La Jolla, United States (Active)
Researchers
- Principal investigator: Lee, Kuo-Fen — Salk Institute for Biological Studies
- Study coordinator: Lee, Kuo-Fen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.