Creating genetically engineered mice for food allergy research
Official title: Transgenic Core
Funded at Food Allergy Science Initiative, INC. · NIH-11088816 · Data updated 2026-11-12
This study is creating special mice to help us learn more about food allergies, which could lead to better treatments and ways to prevent them for people who suffer from these allergies.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Food Allergy Science Initiative, INC. NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project start | May 14, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $345,800 |
| NIH project number | 5P01AI179273-02 |
| Project ID | NIH-11088816 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with food allergies or those interested in genetic studies related to allergic responses.
✕Less likely to help
Patients without food allergies or those not interested in genetic research may not benefit from this research.
What this research studies
This research focuses on developing genetically modified mice to better understand food allergies. The team will create various types of mice, including those with specific genes knocked out or modified, using advanced techniques like CRISPR. These engineered mice will help researchers study how different genes affect food allergies and the underlying mechanisms involved. The project aims to provide valuable insights that could lead to new treatments or preventive strategies for food allergies.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of food allergies, potentially resulting in new therapies for affected patients.
How similar studies have gone: Previous research using genetically engineered mice has shown promise in understanding various diseases, indicating that this approach could be effective for food allergy research as well.
Where this research is happening
-
Food Allergy Science Initiative, INC.
Cambridge, United States Active
Researchers
- Principal investigator: Lowell, Bradford B — Food Allergy Science Initiative, INC.
- Study coordinator: Lowell, Bradford B
Related research
Other NIH-funded projects on the same topics.
-
How gut nerves and immune cells interact in food allergy
This project looks at how contacts between gut nerves, immune cells, and hormone-producing gut cells affect allergic reactions to food for people with food allergies.
-
How mast cells trigger gut lining and nerve responses in food allergy
This project looks at how immune cells called mast cells change the gut lining and nerves in people with food allergies.
-
How nerves and the immune system cause food allergy symptoms
This project explores how nerves and the immune system cause the symptoms people with food allergies feel, like nausea, breathing changes, and low blood pressure.
-
Food allergy data hub
A centralized team will build online tools to analyze genetic and imaging data to help researchers studying food allergies and the people they treat.
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Custom genetically engineered mice for food allergy
This program creates specially modified mice to help scientists better understand and develop treatments for food allergies.
-
How the nerves and immune system affect food allergies
Researchers are looking at how the nervous system and immune system interact in people with food allergies to find better ways to prevent and treat reactions.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.