Creating genetic tools to predict how African Americans respond to medications
Development of Polygenic Scores for Medication Response in Diverse Populations
['FUNDING_R21'] · HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES · NIH-10904500
This study is working to create better tools that help predict how African Americans will respond to medications, using their unique genetic background, so that treatments can be safer and more effective for them.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES (nih funded) |
| Locations | 1 site (EAST LANSING, UNITED STATES) |
| Trial ID | NIH-10904500 on ClinicalTrials.gov |
What this research studies
This research aims to develop polygenic scores (PS) specifically for African American populations to better predict medication responses. Current PS are primarily based on European genetic data, which limits their effectiveness for non-European individuals. By utilizing innovative analytic methods that consider localized ancestry, the project seeks to create more accurate PS that reflect the unique genetic makeup of African Americans. This approach will enhance the understanding of how genetic factors influence medication efficacy and safety in these populations.
Who could benefit from this research
Good fit: Ideal candidates for this research are African American individuals who are taking or may need medications for common chronic conditions.
Not a fit: Patients who are not of African descent or those who do not have common chronic conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective medication treatments for African American patients.
How similar studies have performed: Previous research has shown promise in developing polygenic scores for specific populations, but this approach is particularly novel in its focus on African Americans and medication response.
Where this research is happening
EAST LANSING, UNITED STATES
- HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES — EAST LANSING, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LANFEAR, DAVID E — HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES
- Study coordinator: LANFEAR, DAVID E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Adult-Onset Diabetes Mellitus