Creating drugs to stop cancer by blocking ribosome production
Official title: Developing ribosome biogenesis inhibitors for the prevention of cancer
Funded at Ut Southwestern Medical Center · NIH-11092866 · Data updated 2026-11-12
This study is looking for new medicines that can stop cancer cells from growing by blocking how they make ribosomes, which are important for their growth, and it's aimed at helping people who are at risk for certain cancers, like liver cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | May 21, 2024 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $348,500 |
| NIH project number | 5UG3CA290312-02 |
| Project ID | NIH-11092866 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that predispose them to cancer, such as liver disease.
✕Less likely to help
Patients who are not at risk for cancer or those with advanced cancer may not benefit from this research.
What this research studies
This research focuses on developing new drugs that inhibit ribosome biogenesis, which is crucial for cancer cell growth and proliferation. By using innovative techniques like ribo-SNAP and SidBait, the researchers can study ribosome production in living cells and identify compounds that can effectively block this process. The goal is to find new treatments that can prevent the formation of tumors, particularly in patients at risk for certain types of cancer, such as liver cancer. This approach aims to provide a scalable and efficient method for discovering potential anti-cancer agents.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that prevent cancer development in high-risk patients.
How similar studies have gone: Other research has shown promise in targeting ribosome biogenesis as a strategy for cancer prevention, indicating that this approach could be effective.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Buszczak, Michael — Ut Southwestern Medical Center
- Study coordinator: Buszczak, Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.