Creating DNA sequences quickly and efficiently using existing templates
Official title: Rapid and efficient generation of sequence variants by templated synthesis
Funded at Columbia University Health Sciences · NIH-10726976 · Data updated 2026-11-12
This study is working on a quicker and cheaper way to create DNA with multiple changes, which could help scientists learn more about how cells communicate and function.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 19, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $452,375 |
| NIH project number | 1R21HG013161-01 |
| Project ID | NIH-10726976 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with genetic conditions that could be addressed through advanced genetic therapies.
✕Less likely to help
Patients with conditions that do not involve genetic mutations or those who are not candidates for genetic therapies may not receive benefit from this research.
What this research studies
This research focuses on developing a new method for synthesizing DNA sequences that contain multiple mutations. By using existing DNA sequences as templates, the researchers aim to create these sequences faster and at a lower cost compared to traditional methods. The project will involve designing algorithms for predicting the best sequences, optimizing the experimental processes, and utilizing robotic automation for high-throughput production. The goal is to produce large DNA constructs that can be used to better understand cell signaling and other biological processes.
Why it matters
Potential benefit: If successful, this research could significantly reduce the time and cost associated with generating complex DNA sequences, benefiting various fields including genetic research and therapeutic development.
How similar studies have gone: Previous research has shown promise in using template-guided synthesis for DNA construction, indicating that this approach could lead to significant advancements in the field.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Wang, Harris H — Columbia University Health Sciences
- Study coordinator: Wang, Harris H
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.