Creating detailed 3D maps of tissues using advanced genomic techniques
Official title: Methods to build and annotate tissue atlases using spatial genomic data
Funded at J. David Gladstone Institutes · NIH-10973168 · Data updated 2026-11-12
This study is working on creating detailed maps of human tissues to better understand how different cells interact, especially in healthy and diseased brains, which could help improve treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | J. David Gladstone Institutes NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | September 5, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $829,659 |
| NIH project number | 1R01HG013736-01 |
| Project ID | NIH-10973168 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults with various brain conditions, such as tumors or other neurological disorders.
✕Less likely to help
Patients with conditions unrelated to tissue organization or cellular interactions may not benefit from this research.
What this research studies
This research focuses on developing innovative methods to create three-dimensional atlases of human tissues by utilizing advanced spatial genomic technologies. By analyzing how cells interact within their local environments, the project aims to catalog the diversity of cell types and their states in both healthy and diseased tissues. Patients may benefit from this research as it could lead to a better understanding of diseases, particularly those affecting the brain, by providing insights into cellular organization and interactions. The research will involve collecting and analyzing tissue samples to build these comprehensive atlases.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of complex diseases and improve diagnostic and therapeutic strategies for patients.
How similar studies have gone: Other research has shown promise in using spatial genomic technologies to understand tissue organization, indicating that this approach has potential for success.
Where this research is happening
-
J. David Gladstone Institutes
San Francisco, United States Active
Researchers
- Principal investigator: Engelhardt, Barbara — J. David Gladstone Institutes
- Study coordinator: Engelhardt, Barbara
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.