Creating complex sugars that help understand immune responses
Official title: Programable Modular Synthesis of Sulfated N-Glycans and O-Glycans
Funded at Georgia State University · NIH-11011313 · Data updated 2026-11-12
This study is looking at special sugars in the body that help with immune responses, and it aims to understand how these sugars work with proteins, which could lead to better treatments for conditions like cystic fibrosis and airway infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgia State University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | February 1, 2024 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $294,840 |
| NIH project number | 5R01GM152688-02 |
| Project ID | NIH-11011313 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients with cystic fibrosis or other airway infections who may benefit from advancements in understanding glycan-related immune responses.
✕Less likely to help
Patients with conditions unrelated to glycan interactions or those not affected by airway infections may not receive direct benefits from this research.
What this research studies
This research focuses on the synthesis of sulfated N-glycans and O-glycans, which are complex sugars that play important roles in biological processes and immune responses. By developing a systematic approach to create these glycans, the research aims to uncover their structures and functions, particularly how they interact with proteins in the body. This could lead to a better understanding of conditions like cystic fibrosis and airway infections, as these glycans are believed to influence immune cell behavior. Patients may benefit from insights gained through this research that could inform new treatments or therapies.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with conditions influenced by glycan interactions, such as cystic fibrosis.
How similar studies have gone: While the synthesis of sulfated glycans has been a challenge, similar research approaches have shown promise in understanding glycan functions, indicating potential for success in this novel area.
Where this research is happening
-
Georgia State University
Atlanta, United States Active
Researchers
- Principal investigator: Li, Lei — Georgia State University
- Study coordinator: Li, Lei
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.