Creating complex organic molecules using metal catalysts
Official title: Discovering catalytic strategies for transition metal-catalyzed reactions to construct topologically complex organic scaffolds
Funded at University of Rochester · NIH-10892952 · Data updated 2026-11-12
This study is exploring new ways to make more complex organic molecules that could help improve health, aiming to create better options for treating different health conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | August 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $338,800 |
| NIH project number | 5R35GM150584-02 |
| Project ID | NIH-10892952 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for benefiting from this research are individuals with conditions that could be treated by novel small molecule therapeutics derived from these complex organic scaffolds.
✕Less likely to help
Patients who are not seeking new drug therapies or those with conditions that do not respond to small molecule treatments may not benefit from this research.
What this research studies
This research focuses on developing new methods to create complex three-dimensional organic molecules that can have beneficial effects on health. By using innovative metal catalysts and ligands, the researchers aim to transform simple starting materials into more complex structures that are often missing from current drug discovery libraries. The goal is to enhance the diversity of compounds available for developing new small molecule therapeutics, which could lead to better treatment options for various conditions.
Why it matters
Potential benefit: If successful, this research could lead to the development of new and more effective drugs with improved biological activities.
How similar studies have gone: While the approach of using transition metal catalysis is well-established, the specific focus on sp3-rich organic scaffolds represents a novel area that has not been extensively explored.
Where this research is happening
-
University of Rochester
Rochester, United States Active
Researchers
- Principal investigator: Paradine, Shauna M — University of Rochester
- Study coordinator: Paradine, Shauna M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.