Creating complex amines from simple amino acids using light-based catalysis
Official title: Complex Amines from Simple Amino Acids via Pyridoxal-Mimicking Radical (Photo)Catalysis
Funded at State University New York Stony Brook · NIH-11020752 · Data updated 2026-11-12
This study is exploring a new way to create important building blocks for medicines and other biological materials using light and special tools, making the process easier and more environmentally friendly.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project start | February 1, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $385,298 |
| NIH project number | 1R35GM157011-01 |
| Project ID | NIH-11020752 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals interested in advancements in organic chemistry and those involved in pharmaceutical development.
✕Less likely to help
Patients who are not involved in chemical research or do not have a vested interest in organic synthesis may not receive direct benefits from this research.
What this research studies
This research aims to develop a new method for synthesizing complex primary amines from unprotected amino acids using innovative biomimetic organic synthesis techniques. By employing specially designed scaffolds that mimic pyridoxal phosphate (PLP), the project seeks to utilize visible light to facilitate challenging chemical reactions. This approach could provide a more sustainable and efficient way to access complex molecular structures that are important in various biological processes. The methodology involves overcoming traditional kinetic barriers through novel radical pathways, potentially leading to significant advancements in organic synthesis.
Why it matters
Potential benefit: If successful, this research could lead to more efficient and sustainable methods for producing important compounds used in pharmaceuticals and other applications.
How similar studies have gone: While this approach is innovative, similar biomimetic strategies have shown promise in other research, indicating potential for success.
Where this research is happening
-
State University New York Stony Brook
Stony Brook, United States Active
Researchers
- Principal investigator: Lipshultz, Jeffrey Michael — State University New York Stony Brook
- Study coordinator: Lipshultz, Jeffrey Michael
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.