Creating cell models to study cystic fibrosis
In Vitro Models and Cell Culture Core
This study is all about creating special cell models to learn more about cystic fibrosis and find new gene therapies, and it's designed for researchers who want to help improve treatments for people with CF.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project ID | NIH-10892134 on NIH RePORTER |
What this research studies
This research focuses on developing specialized cell models to better understand cystic fibrosis (CF) and explore potential gene therapies. The team at the University of Iowa collects and processes tissue samples from humans and animals to create well-differentiated epithelial models. They also maintain a biobank of CF and non-CF epithelial tissues, including those with rare mutations, to facilitate various analyses such as gene expression and bioelectric evaluations. Additionally, the Core provides training and technical expertise to other researchers interested in CF.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with cystic fibrosis, especially those with rare genetic mutations.
Not a fit: Patients without cystic fibrosis or those not interested in participating in research related to CF may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and therapies for individuals with cystic fibrosis.
How similar studies have performed: Previous research has shown success in using in vitro models to study cystic fibrosis, indicating that this approach is promising.
Where this research is happening
Iowa City, United States
- University of Iowa — Iowa City, United States (Active)
Researchers
- Principal investigator: Zabner, Joseph — University of Iowa
- Study coordinator: Zabner, Joseph
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.