Creating cancer models from pediatric brain and solid tumors
Official title: CANCER MODELS FROM PEDIATRIC BRAIN AND SOLID CANCERS (CMDC)
Funded at Leidos Biomedical Research, INC. · NIH-11197551 · Data updated 2026-11-12
This study is working to create new models of pediatric cancers, especially brain tumors like DIPG, to help researchers better understand these conditions and develop better treatments for kids battling cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Leidos Biomedical Research, INC. NIH-funded |
| Lab location | 1 site (Frederick, United States) |
| Project start | September 28, 2020 |
| Project end | September 24, 2027 |
| Funding year | 2024 |
| Award (this year) | $522,295 |
| NIH project number | 75N91019D00024-P00008-759102000035-1 |
| Project ID | NIH-11197551 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are pediatric patients diagnosed with brain tumors, particularly those with diffuse intrinsic pontine gliomas.
✕Less likely to help
Patients with non-cancerous conditions or those diagnosed with adult cancers may not receive any benefit from this research.
What this research studies
This research focuses on generating approximately 90 new pediatric cancer models, with around 20 specifically from brain tumors, including diffuse intrinsic pontine gliomas (DIPG). The project aims to utilize existing resources and infrastructure to ensure that these models can be used for further research and treatment development. It involves collecting tumor tissue samples for DNA and RNA sequencing, along with clinical data from patients at the time of sample collection and during follow-up after treatment. The goal is to create community resources that can aid in understanding and treating pediatric cancers more effectively.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options and outcomes for children with brain tumors and other solid cancers.
How similar studies have gone: Similar research efforts have shown promise in developing cancer models, indicating a potential for success in this approach.
Where this research is happening
-
Leidos Biomedical Research, INC.
Frederick, United States Active
Researchers
- Principal investigator: Dmitrovsky, Ethan — Leidos Biomedical Research, INC.
- Study coordinator: Dmitrovsky, Ethan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.