Creating brighter and longer-lasting fluorescent proteins for cell imaging
Engineering photostable fluorescent proteins and biosensors using transcriptomic mining and massive-throughput single-cell screening
['FUNDING_R01'] · BAYLOR COLLEGE OF MEDICINE · NIH-11032834
This study is working on creating special proteins that stay bright even when exposed to light, which will help scientists better watch how cells work over time, especially in important areas like growth, learning, and aging.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BAYLOR COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-11032834 on ClinicalTrials.gov |
What this research studies
This research focuses on developing new fluorescent proteins that do not fade when exposed to light, which is crucial for accurately observing cellular activities over time. By using advanced techniques like transcriptomic mining and high-throughput screening, the researchers aim to identify and engineer proteins that maintain their brightness during imaging. This could significantly enhance the ability to study biological processes in living cells, particularly in areas like development, learning, and aging.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that require detailed cellular imaging for diagnosis or treatment monitoring.
Not a fit: Patients who do not require cellular imaging or have conditions unrelated to cellular activity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved imaging techniques that allow for better understanding of cellular functions and disease mechanisms.
How similar studies have performed: Previous research has shown success in engineering fluorescent proteins, but this specific approach to enhance photostability under two-photon illumination is relatively novel.
Where this research is happening
HOUSTON, UNITED STATES
- BAYLOR COLLEGE OF MEDICINE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ST-PIERRE, FRANCOIS — BAYLOR COLLEGE OF MEDICINE
- Study coordinator: ST-PIERRE, FRANCOIS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.