Creating brain models to study glioblastoma and find new treatments
Official title: Neural organoid models of the immunological microenvironment of glioblastoma for drug discovery applications
Funded at Stem Pharm, INC. · NIH-10761235 · Data updated 2026-11-12
This study is exploring new ways to understand and treat glioblastoma, a tough brain tumor, by creating mini brain models that mimic how the tumor interacts with the immune system, which could help find better treatments for patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stem Pharm, INC. NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | July 11, 2023 |
| Project end | June 30, 2025 |
| Funding year | 2023 |
| Award (this year) | $406,500 |
| NIH project number | 1R41CA281533-01A1 |
| Project ID | NIH-10761235 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with glioblastoma or those interested in experimental therapies for this condition.
✕Less likely to help
Patients with other types of brain tumors or those who are not diagnosed with glioblastoma may not benefit from this research.
What this research studies
This research focuses on glioblastoma, a highly aggressive brain tumor with poor survival rates. It aims to develop human brain organoid models that mimic the tumor's immune environment, allowing researchers to study how glioblastoma interacts with immune cells. By incorporating patient-derived cells and immune cells into these organoids, the project seeks to identify new therapeutic targets and test potential treatments in a lab setting. This innovative approach could lead to breakthroughs in how glioblastoma is treated.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for glioblastoma, improving survival rates and quality of life for patients.
How similar studies have gone: Previous research has shown promise in using organoid models for studying various cancers, indicating that this approach could be effective for glioblastoma as well.
Where this research is happening
-
Stem Pharm, INC.
Madison, United States Active
Researchers
- Principal investigator: Lebakken, Connie S — Stem Pharm, INC.
- Study coordinator: Lebakken, Connie S
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.