Creating brain-like structures from stem cells to study Alzheimer's disease
iPSC-derived Neurovascular Organoids
This study is creating tiny brain models from stem cells to learn more about how blood vessel problems can affect thinking and memory in people with Alzheimer's disease, hoping to find better ways to understand and treat the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University NIH-funded |
| Lab location | 1 site (Nashville, UNITED STATES) |
| Project ID | NIH-10814345 on NIH RePORTER |
What this research studies
This research focuses on developing advanced human brain organoids derived from induced pluripotent stem cells (iPSCs) to better understand the vascular contributions to cognitive impairment and dementia, particularly in Alzheimer's disease. By creating three-dimensional models that mimic the brain's architecture, the research aims to investigate the molecular mechanisms underlying vascular contributions to neurodegeneration. This approach seeks to overcome the limitations of current in vivo models, providing a more representative system for studying these complex diseases. Patients may benefit from insights gained through this research, which could lead to improved understanding and treatment options for Alzheimer's disease.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with Alzheimer's disease or those at risk for developing cognitive impairment.
Not a fit: Patients with non-Alzheimer's forms of dementia or those without cognitive impairment may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into Alzheimer's disease and potential therapeutic strategies that address vascular contributions to cognitive decline.
How similar studies have performed: Other research has shown promise in using iPSC-derived models to study neurodegenerative diseases, indicating that this approach could yield valuable insights.
Where this research is happening
Nashville, UNITED STATES
- Vanderbilt University — Nashville, United States (Active)
Researchers
- Principal investigator: Lippmann, Ethan — Vanderbilt University
- Study coordinator: Lippmann, Ethan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.