Creating brain blood vessel models to study aging and diseases
Reverse engineering zonation-specific and age-specific iPSC-derived cerebrovascular models based on transcriptomic profiling of the human brain
['FUNDING_OTHER'] · JOHNS HOPKINS UNIVERSITY · NIH-10927424
This study is looking at how blood vessels in the brain work by using stem cells to create models that can help us understand brain diseases and aging better, which could lead to new treatments for keeping our brains healthy.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-10927424 on ClinicalTrials.gov |
What this research studies
This research focuses on developing advanced models of brain blood vessels using stem cells to better understand how cerebrovascular dysfunction contributes to brain diseases and aging. By examining the differences in blood vessel cells based on their location and the effects of aging, the researchers aim to create more accurate representations of human cerebrovascular systems. These models will help identify key factors that influence brain health and disease progression, potentially leading to new therapeutic strategies. The approach includes genetic screening to determine which factors can effectively mimic the behavior of human brain blood vessels.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing age-related cognitive decline or those with cerebrovascular diseases.
Not a fit: Patients with acute cerebrovascular events or those without any neurological conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for brain diseases related to aging and cerebrovascular dysfunction.
How similar studies have performed: Previous research has shown promise in using stem cell-derived models to study various aspects of brain health, indicating that this approach could yield valuable insights.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SEARSON, PETER C — JOHNS HOPKINS UNIVERSITY
- Study coordinator: SEARSON, PETER C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.