Creating blood tests to understand children's immune systems better.
Official title: Development and application of pediatric-specific blood transcriptional modules across diverse geographical settings through public data mining
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-11116685 · Data updated 2026-11-12
This study is looking at how children's immune systems work differently based on where they live, using blood samples from kids aged birth to 12 years, to help create better vaccines and treatments just for them.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | February 25, 2025 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $286,791 |
| NIH project number | 1R21AI191085-01 |
| Project ID | NIH-11116685 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include children aged birth to 12 years, particularly those from diverse geographical backgrounds.
✕Less likely to help
Patients outside the age range of birth to 12 years or those not affected by immune-mediated diseases may not benefit from this research.
What this research studies
This research focuses on developing specialized blood transcriptional modules (BTMs) that reflect the unique immune characteristics of children from various geographical backgrounds. By analyzing a large dataset of blood samples from children aged birth to 12 years, the project aims to create a comprehensive understanding of pediatric immune responses. The methodology involves advanced computational techniques to identify and categorize gene sets that are crucial for interpreting immune health in children. This work will help in tailoring vaccines and therapies specifically for pediatric populations, addressing a significant gap in current medical research.
Why it matters
Potential benefit: If successful, this research could lead to improved vaccines and treatments for infections and immune-related diseases in children.
How similar studies have gone: Previous research has shown success in developing transcriptional modules for adult populations, but this approach for pediatric-specific modules is novel.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Hagan, Thomas Lafayette — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Hagan, Thomas Lafayette
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.