Creating biomaterials to improve blood vessel formation for treating ischemia
Dynamic ECM-Mimicking Biomaterials for Ischemia Treatment
This study is exploring a new treatment that uses special materials to help grow new blood vessels in people with peripheral artery disease, which could improve healing and reduce the risk of limb amputation.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas at Austin NIH-funded |
| Lab location | 1 site (Austin, United States) |
| Project ID | NIH-11179736 on NIH RePORTER |
What this research studies
This research focuses on developing engineered biomaterials that mimic the extracellular matrix to enhance the formation of new blood vessels in patients suffering from peripheral artery disease (PAD). By utilizing vascular progenitor cells derived from human induced pluripotent stem cells, the study aims to improve the conditions under which these cells can integrate and form functional vascular networks. The approach involves creating hydrogels that provide specific cues to support the growth and organization of these cells, potentially leading to better recovery from critical limb ischemia. Patients may benefit from a novel treatment that could prevent limb amputation by promoting natural blood vessel formation.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those over 65, who are diagnosed with peripheral artery disease and are at risk of critical limb ischemia.
Not a fit: Patients who do not have peripheral artery disease or those with advanced stages of ischemia that are not amenable to vascular intervention may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a new therapeutic option for patients with critical limb ischemia, potentially reducing the need for amputations.
How similar studies have performed: Previous research has shown promise in using engineered biomaterials for vascular regeneration, indicating that this approach may lead to significant advancements in treatment.
Where this research is happening
Austin, United States
- University of Texas at Austin — Austin, United States (Active)
Researchers
- Principal investigator: Zoldan, Janeta — University of Texas at Austin
- Study coordinator: Zoldan, Janeta
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.