Creating better tools to activate genes using CRISPR technology
Development of potent and predictable Cas9 gene activation tools through high-throughput screening
This study is all about making CRISPR technology better at turning on genes in cells, which could help improve treatments for different health conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11093039 on NIH RePORTER |
What this research studies
This research focuses on improving CRISPR technology to enhance the activation of genes in cells. By using advanced screening methods and computational modeling, the team aims to develop more effective and reliable tools for gene activation. The project will involve testing various gene-activating peptides in different cell types to find the best combinations that consistently boost gene expression. This could lead to significant advancements in genetic research and potential therapies for various conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic conditions that could benefit from enhanced gene expression therapies.
Not a fit: Patients with conditions that do not involve gene activation or those who are not eligible for gene therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide more effective gene activation tools that may lead to new treatments for genetic disorders.
How similar studies have performed: Other research has shown promise in using CRISPR technology for gene activation, indicating that this approach could lead to significant advancements.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Sherwood, Richard I — Brigham and Women's Hospital
- Study coordinator: Sherwood, Richard I
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.