Creating better models for understanding proteins using cryo-EM technology
Reliable model building for cryo-EM
['FUNDING_SBIR_2'] · LIGO ANALYTICS, INC. · NIH-10612108
This study is working on making better 3D models of proteins using a special imaging technique, which will help scientists understand how cells work and create better medicines.
Quick facts
| Phase | ['FUNDING_SBIR_2'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | LIGO ANALYTICS, INC. (nih funded) |
| Locations | 1 site (DALLAS, UNITED STATES) |
| Trial ID | NIH-10612108 on ClinicalTrials.gov |
What this research studies
This research focuses on improving the accuracy of atomic models generated through cryogenic electron microscopy (cryo-EM), which is crucial for understanding cellular processes and designing effective drugs. The project aims to develop automated methods for building and validating these models, addressing challenges related to low-quality images and particle flexibility. By enhancing the model-building process, the research seeks to provide more reliable data for scientists studying proteins and their functions at the molecular level.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research include individuals with diseases that involve protein misfolding or dysfunction, such as neurodegenerative disorders.
Not a fit: Patients with conditions unrelated to protein structure or cellular processes may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate drug designs and treatments by providing better insights into protein structures and cellular processes.
How similar studies have performed: Other research in structural biology has shown success in improving model accuracy through advanced imaging techniques, indicating that this approach has potential for significant advancements.
Where this research is happening
DALLAS, UNITED STATES
- LIGO ANALYTICS, INC. — DALLAS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BROMBERG, RAQUEL — LIGO ANALYTICS, INC.
- Study coordinator: BROMBERG, RAQUEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Disease