Creating artificial tracheas for children with airway defects
Tissue-engineered trachea composites for long-segment airway replacement
This study is working on a new way to make artificial windpipes for kids who have breathing problems due to birth defects or injuries, using special materials to help the new windpipes heal better and work like normal ones.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst Nationwide Children's Hosp NIH-funded |
| Lab location | 1 site (Columbus, United States) |
| Project ID | NIH-10886531 on NIH RePORTER |
What this research studies
This research focuses on developing a new method to create artificial tracheas for children suffering from long-segment airway defects caused by congenital issues or trauma. The team is investigating the use of tissue engineering to create a living organ that can replace damaged airway tissue. They are testing a new composite graft that combines decellularized tissue with resorbable biomaterials to improve the stability and functionality of the grafts. The goal is to enhance the healing process and ensure that the grafts can support normal airway function.
Who could benefit from this research
Good fit: Ideal candidates for this research are pediatric patients under 11 years old who have long-segment airway defects.
Not a fit: Patients with short-segment airway defects or those who do not require airway reconstruction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a viable surgical option for children with severe airway defects, potentially saving lives and improving quality of life.
How similar studies have performed: While tissue engineering for airway replacement is a developing field, previous studies have shown promise in using similar approaches, though clinical outcomes have varied.
Where this research is happening
Columbus, United States
- Research Inst Nationwide Children's Hosp — Columbus, United States (Active)
Researchers
- Principal investigator: Chiang, Tendy — Research Inst Nationwide Children's Hosp
- Study coordinator: Chiang, Tendy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.