Creating antibodies to prevent HIV infection
Engineering of pan-neutralizing anti-HIV envelope antibodies
['FUNDING_R01'] · UNIVERSITY OF MARYLAND BALTIMORE · NIH-10746788
This study is exploring a new way to help prevent HIV by creating special antibodies that can fight off different strains of the virus, which could be a helpful option for people at risk of infection.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MARYLAND BALTIMORE (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-10746788 on ClinicalTrials.gov |
What this research studies
This research focuses on developing broadly neutralizing antibodies (bNAbs) that can effectively prevent HIV infection. By engineering specific antibodies that target the HIV envelope, the researchers aim to create a pan-neutralizing antibody capable of neutralizing various HIV strains. The approach involves using rare resistance variants of HIV to guide the design of these antibodies, ensuring they remain effective against resistant strains. Patients may benefit from this innovative method of passive immunization as a potential preventive measure against HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at high risk of HIV exposure who are seeking preventive measures.
Not a fit: Patients who are already living with HIV or those who do not have risk factors for HIV exposure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a new preventive treatment option for individuals at risk of HIV infection.
How similar studies have performed: Previous research has shown promise in developing similar broadly neutralizing antibodies, indicating potential for success in this approach.
Where this research is happening
BALTIMORE, UNITED STATES
- UNIVERSITY OF MARYLAND BALTIMORE — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SAJADI, MOHAMMAD MOHSENI — UNIVERSITY OF MARYLAND BALTIMORE
- Study coordinator: SAJADI, MOHAMMAD MOHSENI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.