Creating animal models to mimic human diseases for better understanding and treatment.
UAB Pilot Center for Precision Animal Modeling (C-PAM) - Disease Modeling Unit
This study is creating and testing new animal models that mimic human diseases to help researchers better understand how these diseases work and find new treatments, making it easier to study conditions that affect people like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-10914833 on NIH RePORTER |
What this research studies
This research focuses on developing and validating innovative animal models that closely replicate human diseases at both molecular and phenotypic levels. By utilizing model organisms such as C. elegans, zebrafish, mice, and rats, the research aims to analyze human genetic variants that may contribute to various diseases. The models created will undergo thorough characterization to ensure they accurately represent the diseases they are meant to mimic, facilitating preclinical testing and advancing our understanding of disease mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic variants linked to diseases being modeled, particularly those related to ciliopathies, cohesionopathies, rasopathies, and other specified disorders.
Not a fit: Patients without genetic variants associated with the diseases being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments and therapies for patients suffering from a range of diseases.
How similar studies have performed: Previous research has shown success in developing animal models for various diseases, indicating that this approach is both promising and validated.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Kesterson, Robert a — University of Alabama at Birmingham
- Study coordinator: Kesterson, Robert a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.