Creating and studying marmoset models to understand Alzheimer's disease
Generation, Characterization, and Validation of Marmoset Models of Alzheimer's Disease
This study is looking at marmoset monkeys to learn more about the early changes in the brain that happen with Alzheimer's disease, hoping to find new ways to help people with this condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10899732 on NIH RePORTER |
What this research studies
This research aims to develop marmoset models to investigate the early cellular and molecular changes associated with Alzheimer's disease (AD). By utilizing a large colony of marmosets, the team will employ advanced neuroimaging and molecular assays to track the progression of AD from its earliest stages. The study will involve a multidisciplinary approach, combining expertise in genetics, animal model development, and behavioral assessments to provide insights that could lead to new interventions for AD. The ultimate goal is to enhance our understanding of AD mechanisms and support future clinical applications.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for Alzheimer's disease, particularly those with early-onset or late-onset forms.
Not a fit: Patients who are not at risk for Alzheimer's disease or do not have a family history of the condition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding and potentially treating Alzheimer's disease.
How similar studies have performed: Other research has shown success in using animal models to study Alzheimer's disease, but the use of marmosets as a primate-specific model is relatively novel.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Silva, Afonso C — University of Pittsburgh at Pittsburgh
- Study coordinator: Silva, Afonso C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.