Creating advanced Vitamin B6-based antioxidants to reduce chronic inflammation
Official title: Engineering hydrophilic/amphiphilic Vitamin B6-based super antioxidant dendrimers for controlling chronic inflammation
Funded at Central Michigan University · NIH-10515089 · Data updated 2026-11-12
This study is exploring new antioxidants made from Vitamin B6 to help reduce chronic inflammation, which can worsen health issues, and aims to create safer options that won't cause extra stress in the body, potentially helping patients manage their conditions better.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Central Michigan University NIH-funded |
| Lab location | 1 site (Mount Pleasant, United States) |
| Project start | September 1, 2022 |
| Project end | August 31, 2025 |
| Funding year | 2022 |
| Award (this year) | $426,275 |
| NIH project number | 1R15GM147862-01 |
| Project ID | NIH-10515089 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from chronic inflammatory conditions such as asthma, arthritis, or cardiovascular diseases.
✕Less likely to help
Patients with acute inflammatory conditions or those not affected by oxidative stress-related diseases may not benefit from this research.
What this research studies
This research focuses on developing innovative antioxidants derived from Vitamin B6 to combat chronic inflammation, which is linked to various serious health conditions. The approach involves engineering dendrimers, which are branched molecules that can effectively neutralize harmful free radicals without generating additional oxidative stress. By synthesizing these dendritic antioxidants, the research aims to provide a safer alternative to traditional antioxidants that may have pro-oxidant effects in the presence of certain metal ions. Patients may benefit from these new antioxidants in managing conditions exacerbated by inflammation.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for chronic inflammatory conditions, potentially improving patient outcomes and quality of life.
How similar studies have gone: Previous research has shown promise in using engineered antioxidants for health benefits, indicating potential success for this novel approach.
Where this research is happening
-
Central Michigan University
Mount Pleasant, United States Active
Researchers
- Principal investigator: Lee, Choon Young — Central Michigan University
- Study coordinator: Lee, Choon Young
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.