Creating advanced tools for tracking cell lineage at a single-cell level
Developing mutable barcodes for high-resolution single-cell lineage tracing
This study is working on new ways to follow the family tree of individual cells, which is important for understanding how cells behave and what makes them unique, and it's designed for researchers who study different types of cells, including those that can turn into many other cell types.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10907573 on NIH RePORTER |
What this research studies
This research focuses on developing innovative methods for tracing the lineage of individual cells, which is crucial for understanding cell identity and behavior. By utilizing advanced single-cell genomics techniques, the project aims to enhance the resolution of lineage tracing, allowing researchers to track the descendants of single cells without the limitations of current methods. The approach seeks to overcome challenges such as transgene silencing and the need for multiple manipulations, making it applicable to various biological models, including induced pluripotent stem cells (iPSCs).
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that involve cell differentiation and reprogramming, such as certain genetic disorders or cancers.
Not a fit: Patients with stable, non-progressive conditions that do not involve cellular reprogramming or differentiation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate insights into cell development and differentiation, potentially improving treatments for various diseases.
How similar studies have performed: Previous research has shown promise in lineage tracing using single-cell genomics, indicating that this approach could lead to significant advancements in the field.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Vanhorn, Sadie M — Washington University
- Study coordinator: Vanhorn, Sadie M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.