Creating advanced tools for gene editing in mice
Development of Modular CRISPR Genome Editing Technologies and Tools
This study is working on a new way to create special mice that help scientists understand diseases better, making it faster and easier to develop these important research tools.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project ID | NIH-10666490 on NIH RePORTER |
What this research studies
This research focuses on developing innovative CRISPR genome editing technologies to improve the creation of mouse models used in biomedical research. By utilizing a method called Easi-CRISPR, the team aims to streamline the process of generating knockout mice, which are crucial for studying gene functions and disease mechanisms. The approach involves using single-stranded DNA donors to enhance efficiency and reproducibility across various laboratories. This research could significantly reduce the time and resources needed to create genetically modified mice, thereby accelerating scientific discoveries.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would be individuals with genetic disorders that could be modeled in mice for better understanding and treatment.
Not a fit: Patients with conditions that do not have a relevant mouse model or those not involved in genetic research may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to faster and more efficient development of mouse models, ultimately enhancing our understanding of genetic diseases and improving therapeutic strategies.
How similar studies have performed: Previous research has shown success with CRISPR technologies in gene editing, making this approach promising for advancing mouse model development.
Where this research is happening
Omaha, United States
- University of Nebraska Medical Center — Omaha, United States (Active)
Researchers
- Principal investigator: Gurumurthy, Channabasavaiah — University of Nebraska Medical Center
- Study coordinator: Gurumurthy, Channabasavaiah
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.