Creating advanced organoids using synthetic gene technology
Synthetic gene sensors and effectors to redirect organoid development
['FUNDING_R01'] · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · NIH-10774322
This study is working on new tools to help grow tiny, lab-made organs from your own stem cells, which could lead to better treatments and drug testing for patients like you.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (nih funded) |
| Locations | 1 site (CAMBRIDGE, UNITED STATES) |
| Trial ID | NIH-10774322 on ClinicalTrials.gov |
What this research studies
This research focuses on developing synthetic gene sensors and effectors to enhance the organization and function of organoids derived from human induced pluripotent stem cells (hiPSCs). By utilizing mathematical modeling, machine learning, and synthetic biology techniques, the project aims to control the differentiation of cells to form complex tissues with specific functions. The researchers will create tools to monitor and guide the development of these organoids, potentially leading to more effective tissue engineering and personalized drug testing. Patients may benefit from advancements in organoid technology that could improve treatment options and outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that could benefit from advanced tissue engineering or personalized medicine approaches.
Not a fit: Patients with conditions unrelated to tissue engineering or those not requiring personalized drug screening may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatments through improved organoid technology.
How similar studies have performed: Other research has shown promise in using synthetic biology approaches for tissue engineering, indicating potential for success in this novel application.
Where this research is happening
CAMBRIDGE, UNITED STATES
- MASSACHUSETTS INSTITUTE OF TECHNOLOGY — CAMBRIDGE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WEISS, RON — MASSACHUSETTS INSTITUTE OF TECHNOLOGY
- Study coordinator: WEISS, RON
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.