Creating advanced mouse models to study human organ disorders
Genomically rewritten and tailored humanized mouse models for various organ disorders
['FUNDING_OTHER'] · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · NIH-11016368
This study is creating special mice that have human genes to help scientists understand diseases like Alzheimer's and age-related vision problems, so they can test new treatments that might help people like you.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEW YORK UNIVERSITY SCHOOL OF MEDICINE (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11016368 on ClinicalTrials.gov |
What this research studies
This research focuses on developing genetically engineered mouse models that mimic various human diseases, particularly those related to Alzheimer's and age-related macular degeneration. By inserting human DNA sequences into the mouse genome, researchers aim to replicate disease characteristics in these models. This approach allows for the testing of new therapies, including gene therapies and CRISPR techniques, in a controlled environment that closely resembles human conditions. Patients may benefit from the insights gained through these models, which could lead to more effective treatments.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with Alzheimer's disease or age-related macular degeneration.
Not a fit: Patients with unrelated neurological or ocular conditions may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding and treating diseases like Alzheimer's and age-related macular degeneration.
How similar studies have performed: Previous research using genetically engineered mouse models has shown promise in understanding human diseases, indicating a strong potential for success in this novel approach.
Where this research is happening
NEW YORK, UNITED STATES
- NEW YORK UNIVERSITY SCHOOL OF MEDICINE — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BOEKE, JEF D — NEW YORK UNIVERSITY SCHOOL OF MEDICINE
- Study coordinator: BOEKE, JEF D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: age related macular disease