Creating advanced mouse models to study human organ disorders
Official title: Genomically rewritten and tailored humanized mouse models for various organ disorders
Funded at New York University School of Medicine · NIH-11016368 · Data updated 2026-11-12
This study is creating special mice that have human genes to help scientists understand diseases like Alzheimer's and age-related vision problems, so they can test new treatments that might help people like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | May 1, 2025 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $844,954 |
| NIH project number | 1R24OD037800-01 |
| Project ID | NIH-11016368 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals with Alzheimer's disease or age-related macular degeneration.
✕Less likely to help
Patients with unrelated neurological or ocular conditions may not receive direct benefits from this research.
What this research studies
This research focuses on developing genetically engineered mouse models that mimic various human diseases, particularly those related to Alzheimer's and age-related macular degeneration. By inserting human DNA sequences into the mouse genome, researchers aim to replicate disease characteristics in these models. This approach allows for the testing of new therapies, including gene therapies and CRISPR techniques, in a controlled environment that closely resembles human conditions. Patients may benefit from the insights gained through these models, which could lead to more effective treatments.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding and treating diseases like Alzheimer's and age-related macular degeneration.
How similar studies have gone: Previous research using genetically engineered mouse models has shown promise in understanding human diseases, indicating a strong potential for success in this novel approach.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Boeke, Jef D — New York University School of Medicine
- Study coordinator: Boeke, Jef D
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.