Creating advanced mouse models to study human macrophages in diseases
Official title: Novel Humanized Mouse Models For Engraftment of Tissue-Specific Human Macrophage Population
Funded at Univ of Massachusetts Med Sch Worcester · NIH-10849269 · Data updated 2026-11-12
This study is creating special mouse models that can grow human immune cells called macrophages, which are important for understanding diseases like Alzheimer's and AIDS, so researchers can find better treatments for these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project start | July 15, 2024 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $881,450 |
| NIH project number | 1R24OD036199-01 |
| Project ID | NIH-10849269 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals affected by Alzheimer's disease or AIDS, as they may benefit from advancements in treatment strategies.
✕Less likely to help
Patients with conditions unrelated to neurodegeneration or immune system dysfunction may not receive direct benefits from this research.
What this research studies
This research focuses on developing innovative humanized mouse models that can effectively support the growth of human tissue resident macrophages, which play a crucial role in various diseases, including Alzheimer's and AIDS. By utilizing these models, researchers aim to better understand how these macrophages function in human health and disease. The approach involves overcoming limitations of existing models that often fail to replicate the complexity of human immune responses. This could lead to more effective therapies and treatments for conditions associated with neurodegeneration and immune deficiencies.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding and treating diseases like Alzheimer's and AIDS by improving immune responses.
How similar studies have gone: Previous research has shown promise in using humanized mouse models to study immune responses, indicating that this approach could yield valuable insights.
Where this research is happening
-
Univ of Massachusetts Med Sch Worcester
Worcester, United States Active
Researchers
- Principal investigator: Brehm, Michael Allen — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Brehm, Michael Allen
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.